MDA-MB-415细胞源于一名38岁患有乳腺腺癌女性的胸腔积液,MDA-MB-415细胞表达WNT7B癌基因。MDA-MB-415细胞形成平展延伸的上皮细胞样,在电镜下呈现结节,伴随着延伸的微管和微板。MDA-MB-415细胞不容易用胰酶消化。
Established from the peripheral blood of a 17-year-old woman with acute lymphoblastic leukemia (ALL-L2) in 1990; contains the t(17;19)(q22;p13) TCF3-HLF (E2A-HLF) fusion gene
Established from the lymph node metastasis of a 63-year-old woman with anaplastic papillary thyroid carinoma; cells were described in the literature to not produce hormones, but to be partly positive
SUM159PT (人乳腺癌细胞系) (STR鉴定正确)
EB-3细胞源自一名3岁患有Burkitt's淋巴瘤的黑人男孩的B淋巴细胞,EBNA阳性。
人的cDNA中编码GADD45的开放阅读框克隆到表达载体pCMV.3中,转染结肠癌细胞RKO,建立了RKO-AS45-1细胞株。RKO-AS45-1细胞含有稳定整合巨细胞病毒(CMV)启动子的表达载体,RKO-AS45-1细胞系和它的母系RKO一起可用于GADD45对DNA修复、凋亡和药物敏感性研究。